OxyFile #640

AU  - Bocci V
AU  - Valacchi G
AU  - Corradeschi F
AU  - Fanetti G

TI  - Studies on the biological effects of ozone: 8. Effects 
      on the total antioxidant status and on interleukin-8 production.

AB  - Ozone (O3) is a controversial gas because, owing to its 
      potent oxidant properties, it exerts damaging effects on 
      the respiratory tract and yet it has been used for four 
      decades as a therapy. While the disinfectant activity of 
      O3 is understandable, it is less clear how other biological 
      effects can be elicited in human blood with practically 
      no toxicity. On the other hand plasma and cells are endowed 
      with a powerful antioxidant system so that a fairly wide 
      range of O3 concentrations between 40 and 80 microg/ml 
      per gram of blood (approximately 0.83-1.66 mM) are effective 
      but not deleterious. After blood ozonation total antioxidant 
      status (TAS) and plasma protein thiol groups (PTG) decrease 
      by 20% and 25%, respectively, while thiobarbituric acid 
      reactive substances (TBARS) increases up to five-fold. 
      The increase of haemolysis is negligible suggesting that 
      the erythrocyte membrane is spared at the expense of other 
      sacrificial substrates. While there is a clear relationship 
      between the ozone dose and IL-8 levels, we have noticed 
      that high TAS and PTG values inhibit the cytokine production.
      This is in line with the current idea that hydrogen peroxide,
      as a byproduct of O3 decomposition, acts as a messenger 
      for the cytokine induction.

MH  - Antioxidants|*ME
MH  - Interleukin-8|*BI/BL
MH  - Ozone|AD/BL/*PD
SO  - Mediators Inflamm 1998; 7(5):313-7
DP  - 1998
TA  - Mediators Inflamm
PG  - 313-7
IP  - 5
VI  - 7
UI  - 99098434