OxyFile #566

Correlation of Plasma Interleukin 1 Levels with Disease Activity 
in Rheumatoid Arthritis with and without Ozone

Fahmy, Z.
55543 Bad Kreuznach


The mean plasma level interleukin 1 beta was significantly higher 
in 51 patients with rheumatoid arthritis (RA) than in 21 
rheumatoid arthritis patients treated with ozone as control group 
of similar age in both groups.

Plasma IL-1 beta correlated positively with Ritchie joint index, 
pain score, and erythrocyte sedimentation rate and correlated 
negatively with haemoglobin concentration.

These results support the idea that IL-1 beta has a central role 
in the pathogenesis of RA and the ozone has influence of the 
level concentration of IL-1 beta.

IL-1 molecules are polypetides with many biological activities 
related to host defence and tissue remodelling and interest has 
arisen in the pathogenic potential of IL-1 in inflammatory and 
immune diseases.  Two forms of human IL-1 (alpha and beta) are 
encoded by separate genes with inducible expression in 
macrophages, lymphocytes, endothelial cells, and other cells 
types.  IL-1 alpha and beta have only 26% aminoacid homology but 
complete equally for receptors on target cells and have similar 
biological activities.

Many activities of IL-1 are relevant to rheumatoid arthritis 
(RA).  IL-1 increases the release from synovial cells of 
vasoactive agents and mediators of tissue damage (eg, 
prostaglandins, proteinolytic enzymes, and reactive oxygen 
molecules and is a powerful stimulus of bone and cartilage 
resorption.  It also induces the acute-phase response and fever 
and may potentiate chronic inflammation by induction of 
lymphocyte growth factors such as interleukin 2 and its 

Despite the weight of circumstantial evidence for IL-1 as a 
pathogenic mediator in RA, it has not previously been possible to 
correlate IL-1 levels in vivo with clinical disease activity in 
patients because IL-1 measurement in blood and other biological 
fluids has been complicated by interfering factors.

Date: 1995