Oxygen-Ozone Therapy and Omotoxicology Drug in Gonarthrosis L. Cursio, G.Menaldo. Unite Research of Global Medicine, I. P. O. G. Turin, Italy. Gonarthrosis is a disease found more frequently in females ranging 2.1. Some authors maintain that this degenerative arthropathy is the most common kind of arthrosis. It is normally a bilateral condition although at its outset it present monoarticular symptoms. Traumas, congenital malformations (like: genu-valgum and genu-varum) and circulatory affections and meniscus alterations are the most frequently found causes of this diseases. Symptoms: pain seems to be unrelated and spontaneous and it can increase when walking, but mostly when going downstairs; the joint movements are reduced and can be painful when pressure is applied to the inner side of the joint. We have looked for a combined treatment with oxygen-ozone on the acupuncture points and homotoxicology substances such as: cimicifuga, colocynthis, arnica, belladonna . A mixture of oxygen-ozone (15 mL in all), whose concentration was 30 (g/mL, has been injected into the inter-joint space and around it (periarticulation). The patient felt a slight burning sensation which disappeared few minutes after the injection. The homotoxicology substances were thus given: arnica and cimicifuga by us, colocynthis or colocynthis belladonna by subcutaneous route around the joint. The number of patients treated for this case study were 48, between 43 and 62 years of age. Symptoms improved rapidly (after only 3-4 treatments) and night pain was greatly reduced and so was the swelling with a return of joint functions. The total number of treatments for patients was from a minimum of 8 to a maximum of 15, being space twice weekly first and weekly afterwards. Only 5 patients did not have a satisfactory outcome, due to their lack of cooperation. It is concluded that although some patients did not have a total remission of the pain, nevertheless they had the great advantage of not having night pain anymore, a more confortable sleep, less swelling and improved joint movement. Source: 2nd International Symposium on Ozone Applications Havana, Cuba - Mach 24-26, 1997.