OxyFile #483


Ozonation of 5-Fluoroacil and Citarabine in Aqueous Medium

A.S. Padrón, M.E. Martínez, L. García, R. Pérez-Rey(1), C. 
Baluja(1).

Drug Development and Research Center, Cuba.
1 - Ozone Research Center, Cuba.

Wastewaters from pharmaceutical manufactures of citostatic drugs 
are, in principle, polluted with them. These compounds can result, 
under certain circumstances, toxic and even carcinogenics. The 
problem of removing such compounds from water has not been 
completely solved yet. This work comprises the ozone inactivation 
of 5-fluoroacil and citarabine, two nitrogen bases with citostatic 
properties dissolved in water. Results show that both compounds 
can be inactivated by ozonation. The composition of the reaction 
mixture was followed by HPLC and at the end of the reaction, the 
Ames test performed showed that the reaction products resulted non 
mutagenic.


Source: 2nd International Symposium on Ozone Applications
        Havana, Cuba - Mach 24-26, 1997.