Ozonation of 5-Fluoroacil and Citarabine in Aqueous Medium A.S. Padrón, M.E. Martínez, L. García, R. Pérez-Rey(1), C. Baluja(1). Drug Development and Research Center, Cuba. 1 - Ozone Research Center, Cuba. Wastewaters from pharmaceutical manufactures of citostatic drugs are, in principle, polluted with them. These compounds can result, under certain circumstances, toxic and even carcinogenics. The problem of removing such compounds from water has not been completely solved yet. This work comprises the ozone inactivation of 5-fluoroacil and citarabine, two nitrogen bases with citostatic properties dissolved in water. Results show that both compounds can be inactivated by ozonation. The composition of the reaction mixture was followed by HPLC and at the end of the reaction, the Ames test performed showed that the reaction products resulted non mutagenic. Source: 2nd International Symposium on Ozone Applications Havana, Cuba - Mach 24-26, 1997.