OxyFile #466


Total Ozone Therapy of Trophic Ulcers of Lower Extremities in 
Elderly Patients

S. Gorbunov, L. Gorbunova, Ph. Romashov, V. Dmitriev, V. Isaev. 

Medical Institute Of Frontier-Guard Service, The Medical Academy, 
Nizhni Novgorod, Russia. 

Trophic ulcers of foot and crus are known to be a common pathology 
among elderly patients causing frequent loss of working capacity 
and disability, requiring a long course of treatment and having a 
tendency to recurrence. The available current methods of treatment 
do not appear to be sufficient and effective enough. It gives rise 
to a search of new methods for their treatment. Local complex 
treatment, aimed a sanatory and stimulation of spontaneous 
epithelization, seems to be more appropriate for patients of 
elderly and gerontal age, having a lot of accompanied diseases. 
Hence, current treatment principles should be based on agents with 
marked antibacterial properties and simultaneously able to 
eliminate local hypoxia and regulate oxygen dependent processes. 
Medical ozone meets all these requirements. Regarding its medical 
properties, ozone has been used in the complex treatment of 42 
patients with long-term trophic ulcers of foot and crus (age range 
61-8~ years). Complex ozone therapy included local effect of 
gaseous ozone in plastic sac. Besides, for the first 8-10 days the 
ulcer was covered with ozone saturated antiseptic dressing. With 
the signs of marked epithelization, antiseptic dressing were 
substituted by the ones with ozonated olive oil. Ulcers with pyo-
necrotic deposit were covered with ozonated enterosorbents for the 
first 3-5 days. Along with external treatment in plastic sacs, the 
surrounding surface of ulcer was subcutaneously injected with 
ozone/oxygen mixture. With the aim of detoxication, as well as 
normalization of oxygen-dependent processes and improvement of 
microcirculation, all the patients received intravenous injections 
of 250.0 mL ozonated rheopolyglukine, daily. The most efficient 
was found to be a complex treatment of vulnerosorbtion with press 
vacuum external ozone therapy in hard-frame chamber. By the 10  12 
day of treatment the ulcer surface became sterile, epithelization 
rate being not more than 4-5 % a day, starting from the third week 
it reached 11-12 % a day. Only one patient, out of 42, did not 
have a complete cover of ulcerative defect in skin surface.

Source: 2nd International Symposium on Ozone Applications
        Havana, Cuba - Mach 24-26, 1997.