OxyFile #461

Ozone Influence on Pro-Inflammatory Process in Maxillo-Facial Part 
of Head and Neck

E. Durnovo, I. Kinyapina, C. Kontorschikova.

The Medical Academy of Nizhni Novgorod, Russia.

The results of ozone therapy combined with traditional treatment 
of 50 patients with odontogenic maxillofacial phlegmons are 
presented. Ozone was used in concentrations of 1300 g/L for 
intravenous injections of ozonated saline and in concentration of 
4500 g/L and 2000 g/L for local dialysis of wounds and mouthwash 
with ozonated distilled water. A special group consisted of 
patients with severe saprogenous necrotic phlegmons. The lesions 
involved the neck and mediastinal organs. The surgical management 
of such patients often includes tracheostoma and dissection of 
mandibular muscles to provide a better wound drainage. The use of 
ozone resulted in wound clearance from purulent exudate and 
necrosis on the 3-4 day. The wound was shown to have activation of 
mononuclear phagocytes, reinforcement of mesenchymal proliferation 
with parallel intensive development of epithelium covering the 
wound surface. Starting from the first ozonated intravenous 
procedure the patients showed improvement in general condition, 
normalization of body temperature and laboratory blood data, 
activation of general antioxidant system and local immune 
resistance of oral cavity. As a result secondary sutures could be 
done on 7-8 day and in some cases even to suture the wounds 
completely. It helped to avoid disfiguring scars formation.

Source: 2nd International Symposium on Ozone Applications
        Havana, Cuba - Mach 24-26, 1997.