OxyFile #460

Ozone Therapy in Supra-Segmental Vegetative Disorders

S. Kotov, A. Gustov, C. Kontorschikova.

The Medical Academy of Nizhni Novgorod, Russia.

Dropping intravenous infusions of ozonated saline (OS) were used 
in complex treatment of 106 patients (average age 26.5) with the 
syndrome of permanent-paroxysmal vegetative dystonia (mean 
duration of 3.6 years). The most common etiological causes were 
neurosis (20 %), after- effects of closed cranicerebral injuries 
(17 %), psychoemotional tense (16 %), hereditary-constitutional 
factors (14 %). Ozone therapy course included 5 procedures, 
administered every other day. Control group consisted of 24 
patients that were on placebo treatment. 38 patients were treated 
with the use of double blind method. All patients were made 
complex dynamic examination. The results showed that dropping 
intravenous OS infusions  increased the efficiency of complex 
therapy of patients with supra-segemental vegetative disorders, 
decreasing resistance to the performed therapy. OS vegetotropic 
action was found to depend on concentrations, OS with ozone 
concentration of 800 g/L of ozone/oxygen mixtures has vegeto 
modifying properties. It should be adminitered in chronic post-
traumatic headaches, tense headaches with signs outlow 
complications, dysosmia impairment, cardialgias. OS infusions with 
ozone concentrations of 400 g/L of ozone/oxygen mixtures produce 
sympatholytic, trophotropic effect and are recommended in chronic 
and episodic tense headaches, panic attacks, high level of anxiety 
and heliometeodependence. Normalization of integral indexes of 
total cardiointerval variability and cardiac rhythm wave structure 
were regarded as efficiency criteria in ozone therapy of patients 
with supra-segmentary vegetative disorders. Increase of superoxide 
dismutase activitiy in blood was regarded as biochemical 
efficiency criterion. Not producing significant changes in the 
cerebral bloodflow. OS reduces the deficiency of peripheral 
vasoconstriction, improves vegetative activity and 
thermoregulation. OS lows down the tense grade in regulatory 
systems function and increases defence-adjustable capacities of 
vegetative nervous system. Steady normalization of vegetative 
tonus was observed in patients with prevalent sympathic tonus and 
unsteady vegetative tonus when received 5 dropping OS infusions. 
Patients with prevalent parasympathic tonus required repeated 
courses of ozone therapy to maintain the stable vegetative 

Source: 2nd International Symposium on Ozone Applications
        Havana, Cuba - Mach 24-26, 1997.