OxyFile #455

Ozone Plus Cobalt Therapy in Patients Suffering from Prostatic 

L. Borrego, L. L. Borrero, E. C. Díaz(1), S. Menéndez(2), L. R. 
Borrego(3), R. A. Borrego(3).

Provincial Center of Retinitis Pigmentosa, Holguín, Cuba.
1 - V.I. Provincial Center of Retinitis Pigmentosa, Holguín, Cuba.
2 - Ozone Research Center, Cuba.
3 - Faculty of Medicin, Holguín, Cuba.

Prostatic adenocarcinoma is the most frequent tumor in men older 
than 50 years old, representing the 16.7 % of all the death cases 
of cancer in male sex. With an early diagnose and an appropriate 
treatment the survival increase in 5 years, in 91 % of cases. 
Cancer metabolism is fundamentally anaerobic, for that reason, 
increasing oxygenation in damaged tissues, may diminished the side 
effects produced by radiation treatments, as well as increase  
radio-sensibility. The aim of this study is to evaluate the 
efficacy of ozone therapy in conjunction with cobalt-60 therapy, 
in the treatment of patients suffering from  prostatic cancer,  
taking into account the influence that ozone exerts in tissue 
oxygenation. 70 patients with malignant neoplasia in prostate, 
stage A and B of the disease (intracapsular) were treated by an 
oncourology muldisciplinary group of the "Lenin" Hospital (Holguin 
Province). 35 patients were treated with rectal ozone plus cobalt 
therapy (ozone group)  and 35 with cobalt therapy only (control 
group). The appearance of side effects (dermatitis radiation, 
cystitis, proctitis) and the behavior of some humoral and clinical 
parameters were evaluated up to 6 months after finishing the 
treatment.  84 % and 52 % of  side effects were presented in 
control group and ozone group, respectively. Prostatic specific 
antigen (PSA) decrease, less than 10 ng/mL, in 92 % of patients 
treated with ozone and in 52 % in control group, one month after 
finishing the treatment. 88 % and 80 % of clinical and humoral 
control of the disease were obtained in ozone group and control 
group, respectively, 6 months later.  It is concluded that, 
combining cobalt therapy with ozone, a decrease in side effects 
and an increase in radio-sensibility were achieved.

Source: 2nd International Symposium on Ozone Applications
        Havana, Cuba - Mach 24-26, 1997.