OxyFile #438

The Reversal of Scleroderma Report of Two Cases

Description: The procedures used for the arresting of the progress of 
two cases of severe scleroderma and the return of the patients to near 
normal health and activity. One patient was treated with intravenous 
EDTA and DMSO, and with oral anti-amoebics, the other patient with 
intravenous EDTA and DMSO, alternating with intravenous H202, and oral 

Title: The reversal of scleroderma(progressive systemic sclerosis), 
report of two cases.

Davis, RM

Abstract: This is a report of the reversal of two cases of scleroderma, 
the first case that of a fifty year old white female with severe kidney 
involvement, treated with intravenous EDTA and DMSO therapy, and 
Metranidazole and Allopurinol tablets(according to the Rheumatoid 
Disease Foundation protocol). The second case is of a fifty-five year 
old Mexican female  with early disease, but having rather severe 
involvement of the hands, face, and arms. She was treated with a 
combination of intravenous EDTA & DMSO therapy, alternating with 
intravenous H202(0.03%). Metranidazole and Allopurinol tablets were 
also used with this patient. The response of these patients to the 
described therapies is outlined in this report. Conventional therapies 
had failed in both patients.

Scleroderma is among the connective tissue diseases, which include 
systemic lupus erythematosus, rheumatoid arthritis, polymyositis-
dermatomyositis, Sjogrens Syndrome, and mixed connective tissue 
disease. They are characterized by chronic inflammation, and a 
dysfunctional immune system, involving joints, serosal membranes, 
connective tissue and blood vessels in multiple organs (1). Kidneys and 
lungs are the organs most commonly affected.

The standard treatment for scleroderma consists of large doses of 
steroids and methotrexate as well as other anti-cancer agents and gold 
therapy. These treatments, while at times do offer some relief from the 
disease, are attendant with unwanted, severe, and sometimes fatal side 
effects. Death due to the ravages of the disease is the eventual 
outcome, although some cases of spontaneous remission have been 
reported, they are very rare.

Case 1. This first case of scleroderma was a forty-nine year old lady 
who had been told by her rheumatologist at the Houston Medical Center, 
that there was nothing more he could do for her. The patient was 
terminally ill and she wanted to take our therapy, as she had been 
given no hope of recovery.

The patient first began to notice a sensation of swelling and tightness 
of the skin, face, and extremities approximately two years prior to 
being seen in our office May 22,1984. These symptoms rapidly progressed 
to the point of rendering the patient unable to walk, or do daily 
household work. Evidently her kidneys had become affected early in the 
disease, as hypertension and headache were early symptoms. The patient 
had been on antihypertension medication for over one year, and on 
peritoneal dialysis for nearly nine months, before being seen in our 
office. She was under the care of a rheumatologist in Houston, and the 
Texas Kidney Institute at Hermann Hospital in Houston.

Medications being taken as of May 22, 1984:
Dialome - 1 t.i.d.
Compazine -25 Mg. tabs i. q.i.d. for nausea.
Capoten - 75 Mg. i. b.i.d. 
Prednisone - 5 Mg i. daily.
Catapres - o.1 Mg 1 @ hs.
Peritoneal dialysis with 1 liter of solution(prepared by The Texas 
Kidney Institute at Hermann Hospital) in Houston.

Physical Examination:
BP 140/90  P 94  T 100/O  R 20  Ht 60"  Wt 109#
The patients' skin was white and glistening, and appeared to have been 
stretched tightly over the bony skeleton. The joints at the elbows, 
wrists, knees, and ankles very difficult to move. The fingers were 
fixed in flexion and could not be moved at all. She had the classic 
Mauskopf face.

Initial Laboratory Data:
Hgb.  WBC  Ca++ BUN Creat. Gluc. Trig. Uric A. SGOT SGPT Prot. Alb.
8.4  7400  9.3  91   8.3    113   377   6.6     28   23   7.0  3.7

Glob. LDH Phos. 24hr Creat Cl. Na+ K+ Cl- Co2
3.3   204  4.6       7.0       140 5.0 100 24

Urinalysis: S.G.1.010 Ph 5.0 Prot. 1+ Gluc. - Casts 2+rbc Bact. 1+ rbc 
4-5/hpf wbc 3-4/hpf.
Chest X-ray: Negative
EKG: Sinus tachycardia, otherwise normal.

Impression: Progressive Systemic Sclerosis (Scleroderma)
            Nephrosclerosis with kidney failure secondary to
            Severe Anemia secondary to the two conditions above

Treatment Plan:
 1. Anti-Amoebic therapy
 2. I.V DMSO therapy
 3. I.V. Chelation therapy.
 4. Physical therapy as tolerated by the patient,

clinical course: On May 22, 1984 anti-amoebic therapy was initiated in 
accordance with The Rheumatoid Disease Foundation protocol, which is as 
follows; Zyloprim 300 Mg t.i.d. for 7 days. Flagyl 500 Mg - two tablets 
A.M. and P.M. on two consecutive days a week for six weeks(2). The 
patient was told to continue all current medications. She experienced 
increased nausea and headache, plus she had severe joint pains as well 
as increased muscular aces and pains. These symptoms were thought to be 
due to a Herxheimer type reaction, for they were most bothersome  
following taking the Flagyl on Tuesdays and Wednesdays. 

On 7/27/84 the patient received an IV of 5cc of Rimso 50 (50% DMSO) in 
500cc D5W over 3 hr. timespan, without untoward effects(3). These 
infusions were continued three times weekly, increasing the Rimso 50 by 
10cc per treatment until the maximum dose of 50cc of Rimso 50 was 
reached. This dosage was decided upon following a telephone 
conversation with Dr. Stanley Jacob of the University of Oregon, this 
being his protocol for the treatment of scleroderma(8/27/84).

By the fourth month of therapy, the Prednisone had been gradually 
withdrawn and discontinued, kidneys regaining function and patient able 
to walk without assistance. Seven months after the initiation of 
therapy, enough kidney function had returned to allow stopping 
dialysis. The patient was feeling well and appeared well in all 
respects. She still had some restriction of motion of the fingers, but 
was improving steadily, and skin had lost its shiny slick look.

One year after beginning therapy, the patient's condition had improved 
to the point that it was felt we could begin adding EDTA to the 
infusions. This was done 5/30/85, at which time 1cc of EDTA was added 
to the iv as was 15cc ascorbic acid, and 2cc B-6, and given over three 
hours. No side effects were noted. Pts. Creat. was 2.8, her clearance 
was 21.7.

The EDTA was gradually increased to 8cc as the patients kidney function 
continued to improve. She continued improving on treatments monthly 
until she pronounced herself "cured" on 10/1/87. She has been on only 
one medication since that time, that medicine being Capoten 75Mg i. 
daily and Catapres 0.1 Mg @ Hs. The patient is leading an active, 
normal life.

Case 2: This fifty-five year old Mexican female presented with 
tightness and swelling of face, hands, arms and feet. Her symptoms 
began approximately one year prior to coming to our office. She had had 
surgery on the right wrist for carpal tunnel syndrome in December 1990. 
She was supposed to have the other wrist operated on too, but since she 
did not improve after the first surgery, it was decided not to operate 
on the other wrist. She was being treated at Lyndon B. Johnson Hospital 
in Houston, Texas.

Medications being taken 8/12/91.
1. Acetaminophen w/codeine #3 2 tabs q 4-6 hrs. prn pain.
2. Tylenol 5oo Mg. 1 tab q 4 hrs.
3. Pen V-K tabs 250Mg. 1 tab q 6 hrs.
4. Cephalexin 250 Mg. caps 1 capsule q 6 hrs.
5. Procardia caps, 10Mg. 1 capsule t.i.d.
6. Hydroxyzine 250Mg. tabs 1 tab q 4-6 hrs. prn itching.
7. Cuprimine 250Mg. caps 1 cap b.i.d.
8. Ibuprofen 400Mg. caps 1 tab t.i.d.
9. Flexeril 10Mg. tabs 1 tab b.i.d.
10. Tagamet 300Mg. tabs 1 tab q.i.d.
11. Zantac 150Mg. tabs 1 tab b.i.d. 

Physical Exam:
BP 120/80  P 74  T 99  R 16  Ht. 62"  Wt. 178#
Physical findings were limited to the skin and joints. There was 
difficulty moving the hands and fingers. The fingers were fixed in a 
mild degree of flexion and patient was unable to close her fists. The 
skin of the hands and arms, to the mid humerus level was darkened and 
very firm and painful to the touch. The feet and toes were similar to 
the hands, as the toes could not be moved, and were edematous. The 
patient's skin of the feet and legs to her knees was of a darkened 
color similar to the arms. The skin of arms and legs had a glistening, 
shiny, slick appearance.

Laboratory Data: Done at LBJ Hosp. 8/12/91
Pulmonary function study was normal.
Blood studies, serum electrolytes, smac 28 were wnl.
Hgb 11.8  Hct 35.6  ESR 50 RA neg ANA Pos 1:320 Speckled pattern
Sjogren Antibodies A and B negative
Scleroderma antibodies Pos 1:640
X-rays Barium swallow negative Chest X-ray Mild cardiomegaly.
EKG Not done

1. Progressive Systemic Sclerosis (Scleroderma).
2. Carpal Tunnel Syndrome, secondary to scleroderma,(operated);
3. Anemia, mild, secondary to 1
3. Possible mild asymptomatic cardiomyopathy secondary to 1.

Treatment Plan:
1. Anti-Amoebic therapy
2. I.V. Chelation-Dmso Therapy.
3. I.V. Hydrogen Peroxide Therapy.
4. Physical Therapy as tolerated by the patient.
5. MSM p.o. q.id.

Clinical Course: The ant-amoebic therapy was started on 8/14/91. 
Moderate Herxheimer reaction was noted on the first two episodes of 
taking the medication, but was hardly noticeable the next four 
treatment episodes. At the same time, iv infusions of chelation-DMSO 
were started and continued three times weekly. There was gradual but 
quite evident improvement in the patients condition over the next year. 
In September 1992, iv H202 was started three times weekly instead of 
the chelation-Dmso infusions. 2.5cc of 3% H202 in 250cc D5W, with 1.6cc 
NaHCO3 was the formula used in the treatment(4). This was a 0.03% 
solution of H202.

the response to this therapy was immediate and dramatic, as the patient 
began to have softening of the tissues of the hands, arms, feet, and 
legs almost within the first week of treatment. She stated that the 
peroxide treatment made her "itch on the inside" of her hands, arms and 
feet, but the next day after the infusion she felt a lot better. She 
felt that the peroxide infusions were giving much better results than 
the chelation-Dmso infusions. Her condition continued to improve with 
each infusion and between infusions, even when she went 2-3 months 
between treatments. She has had a total of 80 chelation-DMSO infusions 
and 30 H202 infusions, and her condition is continuing to improve. The 
skin of her face, arms, hands, legs, and feet is normal in appearance 
and texture. She no longer has fatigue and maalaise, and her energy and 
activity levels are normal. She has normal function of her hands and 
fingers, and is without pain.

Discussion:There seemed to be a better response of the second patient 
to H202 therapy than the chelation-DMSO therapy. It is difficult to 
compare the two cases, for the lady in case 1 was more acutely ill with 
systemic disease, which the lady in case 2 did not have, however their 
overall responses to treatment was excellent, albeit quite different. 
It was the patient in case two's opinion, and my opinion that the H202 
infusions were superior to the Chelation-DMSO infusions. I shall 
continue to use both therapies, but will begin with H202 infusions, as 
well as the anti-amoebic therapy in the future.


1. Mukerji Baasanti, Alpert Martin A. Hardin Joe G When the lungs are 
involved by connective tissue disease. Postgraduate Medicine 
2. DI Fabio,A Rheumatoid Diseases CURED AT LAST Franklin TN,1982 
Rheumatoid Disease Foundation Rt. 4 Box 137 Franklin TN 37064
3. Halstead BW, Youngberg S. The DMSO Handbook Colton CA 1981 Golden 
Quill Publishers Inc. P.O Box 1278 Colton CA 92324
4.Farr CH Workbook on Free Radical Chemistry and Hydrogen Peroxide 
Metabolism including protocol for the intravenous administration of 
hydrogen peroxide Oklahoma City OK 1989 IBOM Foundation P.O. Box 891954 
Oklahoma City, OK 73189
5. Cranton EM, Bypassing Bypass Medex Publishers Inc. Ripshin Rd., P.O. 
Box 44 Troutdale VA 24378-0044 1982
6. Halstead BW The Scientific Basis of Chelation Therapy, Colton, CA 
1979 Golden Quill Publishers Inc. P.O. Box 1278 Colton CA 92324
7. Cranton EM A Textbook on EDTA Chelation Therapy J of Adv Med 2(1/2) 
8. Douglas WC Hydrogen Peroxide MEDICAL MIRACLE Atlanta GA 1992 Second 
Opinion Publishing P.O. Box 467939 Atlanta GA 30346-7939 

Author: Ronald M. Davis, M.D. 5002 Todville, Seabrook, TX 77586

Stanley W. Jacob, M.D., Oregon Health Sciences Univ. Portland OR. For 
his time and explanation of his DMSO protocol, and for seeing pt. 1 in 
Charles H. Farr MD, PhD , for the many interruptions in his busy 
schedule, to assist in the care of both of the patients, with answering 
questions about protocols of EDTA, DMSO, and H202 therapies.
Garry Gordon, MD 5335 Compass Tempe AZ 85283 without whose help I would 
probably not have gotten involved in chelation and other alternative  
Katy Thompson, M.D., Texas Kidney Institute, Hermann Hospital, Houston, 
Texas for her kind assistance and co-operation in the care of the 
patient in case 1

1. Davis
4. H202
5. Anti-amoebics
6. Collagen
7. Scleroderma
8. Sclerosis
9. Herxheimer