The effect of hyperbaric oxygen on different phases of healing of ischaemic flap wounds and incisional wounds in skin. Quirinia A; Viidik A Department of Connective Tissue Biology, University of Aarhus, Denmark. Br J Plast Surg, 48: 8, 1995 Dec, 583-9 Abstract Several studies have revealed a positive effect of treatment of ischaemic wounds and flaps with hyperbaric oxygen. We studied the effect of 100% oxygen (2.4 ATA) for 90 min daily on different phases of healing ischaemic and normal incisional wounds in rats. Hyperbaric oxygen on day 0-3 significantly increased almost all the force parameters of ischaemic flap wounds by 41-57% after 10 days of healing. On the other hand, when the treatment was continued until day 9 the positive effect on the wound healing was abolished. Furthermore, when hyperbaric oxygen was given on days 4-9 there was a tendency towards a decrease in the biomechanical parameters. Hyperbaric oxygen had no effect on the healing of normal incisional wounds.