OxyFile #375

Medical Ozone in the Treatment of lower Extremities Peripheral 
Circulation Disorders

S.N. Gorbunov, N.A. Mironov, S.P. Alyokhina, G.M. Pikalova

Nizhegorodski Reginal Hospital of War Veterans
Ozon Therapy Center
N. Novgorod

Atherosclerotic vessels disorders of the lower extremities are the 
most common pathology in advanced age groups of patients.  It is 
considered to be one of the "civiliration discase" manifestations 
that lead to non-healing trophic ulcers and even to gangrene of 
extremities, that might cause invalidism and in some cases results in 
fatal outcomes.  The common treatment to prevent atherosclerotic 
disorders and the use of vasodilators do not prove to be effective.  
Surgical interventions into vegetative nervous system provide a rare 
steady clinical effect either.

We have observed 132 patients in the age group of 62-84, all of them 
being war invalids with III-IV grade peripheral circulation disorder 
in lower extremities.  All the patients had intermittent 
clandication, shorting of walking distance down to 150-200 m, cooling 
in the extremities and pains in calf muscles (musculus 
gastrocnemius), 31 patients had circulation disorders complicated by 
trophic ulcers the size of which being in the range of 5-32 sg. cm 
and duration in the range of 2-18 years.

11 patients had crus and femur wounds of 47-50 years standing.  
Anamnesis of 8 patients indicated frostbite episodes during the war.  
All the patients had repeatedly received traditional medical 
treatment before ozone therapy was administered, 3 patients having 
had unilateral and bilateral sympathectomy.  It should be noted that 
while ozonetherapy was administered to all the patients, its methods 
were different.

The first group of patients received 8-10 intravenous injections of 
ozonesaturated rheopolyglucin solutions (rheamacrodex) in the dosage 
of 400,0 ml.

In the second group of patients intravenous ozone administration was 
combined with subcutaneous injections of gaseous ozone.

The third group of patients in addition to the first tow methods of 
ozone introduction received 3-4 seance of major ozone autohematherapy 

Patients with trophical ulcers were administered external ozonization 
in plastic bags.  By the end of the treatment course all the patients 
noted significant improvement of their well-being with clinical 
evidence of the lack of pains or cramps in calf muscles and warming 
of the extremities.  There was also noted a 10-15 fold increase in 
the walking distance.  The combined ozonetherapy provided the most 
rapid clinical improvement.  There increased blood saturation with 
oxygen and its voltage in vascular bed (channel) and tissues.  In all 
the cases the ulcerous surface epitalization rate was up to 2-4 sq. 
cm a day.  In two patients ozonated vulvosorbtion was done to 
stimulate the epitalization process.  Surgical intervention was not 
needed for the heavy of trophic ulcers.  The received data prove 
complex ozonetherapy to be highly effective in the treatment of lower 
extremities peripheral circulation disorders in the patients of the 
advanced age group.

Date: 1995