OxyFile #355

Decrease of blood cholesterol and stimulation of antioxidative 
response in cardiopathy patients treated with endovenous ozone 

Hernández F; Menéndez S; Wong R

Ozone Research Center, National Center for Scientific Research, 
Havana, Cuba.

Free Radic Biol Med, 19: 1, 1995 Jul, 115-9


Patients with cardiac infarction show a decrease in glutathione 
peroxidase and superoxide dismutase activities, which are 
beginners in the scavenger processes of lipid peroxide and 
superoxide radicals, respectively. In this study, we investigate 
the effects of endovenous ozone therapy on serum lipid pattern and 
on antioxidant defense system, such as te glutathione redox one, 
in the blood of patients with myocardial infarct. Twenty-two 
patients who had an infarction, between 3 months and 1 year before 
the study, were treated with ozone by autohemotherapy during 15 
sessions. A statistically significant decrease in plasma total 
cholesterol and low density lipoprotein was observed. High 
biologically significant increases on erythrocyte glutathione 
peroxidase and glucose 6-phosphate dehydrogenase activities were 
found. There was no change in plasma lipid peroxidation level. It 
was concluded that endovenous ozone therapy in patients with 
myocardial infarction has a beneficial effect on blood lipid 
metabolism, provoking the activation of antioxidant protection