OxyFile #353

Hyperbaric oxygen, oxygen-ozone therapy, and rheologic parameters 
of blood in patients with peripheral occlusive arterial disease.

Verrazzo G; Coppola L; Luongo C; Sammartino A; Giunta R; Grassia 
A; Ragone R; Tirelli A

Department of Gerontology, Geriatry and Metabolic Diseases, Second
University of Naples, Italy.

Undersea Hyperb Med, 22: 1, 1995 Mar, 17-22


For many years, clinical practice has consolidated the use of both 
hyperbaric oxygen and oxygen-ozone therapy in the treatment of 
peripheral occlusive arterial disease (POAD). We investigated the 
influence of these treatments on hemorrheologic parameters that 
play an important role in the pathogenesis and the clinical course 
of arteriosclerosis. Two groups of 15 patients suffering from 
POAD, assigned at random either to a cycle of HBO therapy or O2-O3 
therapy, were evaluated for blood viscosity, erythrocyte 
filterability, hematocrit value, fibrinogen concentration, and 
thrombin time. The O2-O3 therapy caused a significant increase of 
erythrocyte filterability and a significant decrease of blood 
viscosity. By contrast, HBO therapy did not produce any 
significant change. The increase of lipid peri-oxidation, proved 
by raised malonyldialdehyde plasma levels, seems a likely 
mechanism involved in the hemorrheologic effects of O2-O3 therapy.