OxyFile #286

Ozone Treatment in Mastitis, Metritis and Retention of Fetal Membranes in the Dairy Cow

Scrollavezza P1, Ablondi M2, Pogliacomi B2, Guareschi D2, Dall'Aglio R3, Poldi R1, Pezzoli G1.

1 - Study University of Parma, Italy
2 - DVM, Parma, Italy
3 - DM, Parma, Italy

Presented in Havana, Cuba, 1997.

Mastitis, metritis and retention of fetal membranes are diseases that may affect any species, but are of greatest economic importance in the dairy cow.

MASTITIS AND METRITIS ECONOMIC LOSS

MASTITIS
inflammation of the mammary gland

CONVENTIONAL TREATMENT OF THE BACTERIAL MASTITIS

ANTIBIOTIC TREATMENT OF THE BACTERIAL MASTITIS

METRITIS
inflammation of the muscolar and endometrial layers of the uterus

ENDOMETRITIS
inflammation of the muscolar and endometrial layers of the uterus often observed during estrus

METRITIS ETIOLOGY

CONVENTIONAL METRITIS TREATMENT

OZONE MASTITIS LOCAL TREATMENT

OZONIZED AUTOEMOTHERAPY

OZONE ACTIONS MECHANISM ON PATHOGENIC ORGANISM

  1. Direct on the Pathogen
  2. Indirect on the Immunosystem

OZONE VS ANTIBIOTIC

OZONE EFFICACY:
  • ozone can sterilize all the pathogenic organisms (bacteria, virus, mycetes, yeast) and work against their toxines
  • antibacterial effects are the same or enhanced when mixed with milk
  • local insufflation can reach the milk compartments of the gland
  • ozone work always and faster; sometimes only 1 treatment can cure the inflammated udder or uterus
    • no associated pathogen resistance is known
ANTIBIOTIC EFFICACY:
  • antibiotic can sterilize (not always) only one kind of bacteria or fungi
    • it doesn't work against viruses and yeast
    • it doesn't work with pathogenic organism toxines
  • antibacterial effects tend to decrease when mixed with milk
  • local antibiotics can't reach the occluded milk ducts; so this treatment must to be associated with the parenteral antibiotic treatment
  • antibiotic treatment takes at least 3 days
    • the pathogens grown in vitro aren't often the mastitis agent
    • the right antibiotic is often inefficient in vivo because of antibiotic resistance
OZONE INTERACTION
  • ozone doesn't have any adverse interaction with other drugs or with the gastrointestinal flora; ozone enhances the efficacy of other drugs
ANTIBIOTIC INTERACTION
  • most antibiotics interact with other drugs and with the gastrointestinal flora unpredictably
OZONE ADVERSE REACTION
  • no allergic reaction shown at therapeutic concentrations
  • hipoglycemia can occur sometimes, after ozonized autoemotherpy
ANTIBIOTIC ADVERSE REACTION
  • all antibiotics show a degree of adverse reaction, even at therapeutic concentrations
  • antibiotic can often cause topic or general allergic reaction
OZONE AND MILK UTILIZE
  • milk of the affected mastitis and metritis cow trated with ozone can be utilized immediately for industrial or nutritional purpose
ANTIBIOTIC AND MILK UTILIZE
  • milk of the affected cow treated with antibiotic can't be utilized for industrial or nutritional purpose, at least for 5 days
OZONE AND MEAT UTILIZE
  • after ozone treatment, meat can be utilized immediately for industrial or nutritional purpose
ANTIBIOTIC AND MEAT UTILIZE
  • after ozone treatment, meat can be utilized for industrial or nutritional purpose only after withdrawal time (3 to 30 days or more)
OZONE AND IMMUNOSYSTEM
  • ozone can be utilized as immunostimulant or immunosoppressor only changing the route and the rate of the concentrations
ANTIBIOTIC AND IMMUNOSYSTEM
  • antibiotic often acts some time as immunostimulant and often as immunosoppressor, but these actions aren't predictable and wished for
OZONE AND ANTI-INFLAMMATORY ACTION
  • depending on the concentrations, ozone has an inflammatory/anti-inflammatory action and can be used to modulate flogosis
ANTIBIOTIC AND ANTI-INFLAMMATORY ACTION
  • antibiotic doesn't act on the inflammation process; when it acts, its action is impredictable
OTHER EFFECT OF OZONE
  • ozone autoemotherapy enanched the metabolic rate via a lot of ways
  • ozone autoemotherapy can cure toxiemia
  • ozone treatment can increase the milk production like the bovine somatotropine administration (from 5 to 30%)
  • after ozone treatment the relapse mastitis time is delayed
OTHER EFFECT OF ANTIBIOTIC
  • antibiotic doesn't have metabolic neither detoxicant properties and often cause liver, renal and gastrointestinal damages
  • antibiotic don't increase the milk production
  • after antibiotic treatment is easy to have relapse of the mastitis, because the antibiotic destroyes the micro-ambiental flora

OZONE COST TREATMENT

MASTITIS ECONOMIC LOSS

MASTITIS OZONE TREATMENT AND ECONOMIC LOSS

METRITIS ECONOMIC LOSS

METRITIS OZONE TREATMENT AND ECONOMIC LOSS

WE TREATED ABOUT 5.000 MASTITIS CASES IN THE DAIRY COW

WE TREATED ABOUT 1.000 METRITIS CASES IN THE DAIRY COW


NUMBER OF INSEMINATION/PREGNANCY IN A GROUP OF 20 COWS TREATED WITH OZONIZED OVULI BEFORE ARTIFICIAL INSEMINATION VS 20 COWS NOT TREATED (6 MONTHS PERIOD)

IN THE TREATMENT OF MASTITIS AND METRITIS DISEASE IN THE DAIRY COW OZONE TREATMENT IS

WHY OZONE TREATMENT IN THE MAMMARY GLAND AND UTERUS PATHOLOGIES OF THE DAIRY COW IS NOT USUALLY USED IN THE BOVINE PRACTICE?

WHY OZONE TREATMENT IN THE MAMMARY GLAND AND UTERUS PATHOLOGIES OF THE COW IS NOT USUALLY USED IN THE BOVINE PRACTICE?

* RESOLUTION *