OxyFile #269

TI    Synthesis of 4-hydroperoxy derivatives of ifosfamide and 
      trofosfamide by direct ozonation and preliminary antitumor 
      evaluation in vivo.
AU    Hohorst-HJ; Peter-G; Struck-RF
SO    Cancer-Res. 1976 Jul; 36(7 PT 1): 2278-81
ISSN  0008-5472
LA    ENGLISH
CP    UNITED-STATES
PT    JOURNAL-ARTICLE
UI    76208091

Abstract

A one-step synthesis of 4-hydroperoxyifosfamide and 4-
hydroperoxytrofosfamide is described. The method involves direct 
ozonation of ifosfamide and trofosfamide and offers improved yields 
in comparison with Fenton oxidation and greater convenience in 
comparison with ozonation of the appropriate 3-butenyl 
phosphorodiamidate. Evaluation of the 4-hydroperoxy derivatives of 
cyclophosphamide, ifosfamide, and trofosfamide against leukemia L1210 
in vivo suggests a superior effect for the ifosfamide derivatie.