TI Synthesis of 4-hydroperoxy derivatives of ifosfamide and trofosfamide by direct ozonation and preliminary antitumor evaluation in vivo. AU Hohorst-HJ; Peter-G; Struck-RF SO Cancer-Res. 1976 Jul; 36(7 PT 1): 2278-81 ISSN 0008-5472 LA ENGLISH CP UNITED-STATES PT JOURNAL-ARTICLE UI 76208091 Abstract A one-step synthesis of 4-hydroperoxyifosfamide and 4- hydroperoxytrofosfamide is described. The method involves direct ozonation of ifosfamide and trofosfamide and offers improved yields in comparison with Fenton oxidation and greater convenience in comparison with ozonation of the appropriate 3-butenyl phosphorodiamidate. Evaluation of the 4-hydroperoxy derivatives of cyclophosphamide, ifosfamide, and trofosfamide against leukemia L1210 in vivo suggests a superior effect for the ifosfamide derivatie.