OxyFile #265

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TI    Further experimental investigations on the therapy of gas 
      gangrene with ozone and oxygen (author's transl)
AU    Stanek-VG; Mittermayer-H; Rotter-M; Gruber-H
SO    Wien-Klin-Wochenschr. 1976 Feb 20; 88(4): 141-4
ISSN  0043-5325
LA    GERMAN
CP    AUSTRIA
PT    JOURNAL-ARTICLE
UI    76272949

Abstract:

In continuation of a recently-published investigation on the effect 
of intramuscular injections of an ozone-oxygen mixture on 
experimental gas gangrene in the guinea pig, 2 additional experiments 
were performed in order to establish the efficacy of the therapy when 
given twice daily instead of only once. Futhermore, the effect of an 
analogous therapy was investigated with the use of pure oxygen. The 
ozone-oxygen therapy reduced the death rate from 100% in untreated 
control animals to 73.6 and 70.0%, respectively, in the 2 series of 
experiments. The median survival times were prolonged from 0.56 and 
1.33 days to 5.50 and 6.66 days. The use of oxygen twice daily 
reduced the death rates significantly even further to 57.0 and 47.9%. 
With this therapy the median survival time was increased to 8 and 
more than 12 days. The differences in therapeutic effect of the 2 
gases were not, however, statistically significant. On account of its 
simple applicability previous experiments on animals it is proposed 
that this therapy be employed also in cases of human gas gangrene. In 
addition, the bactericidal effect of CaCl2, as used in this 
experimental study, on vegetative forms of Clostridia is 
demonstrated.