AU - Carpendale MT, Freeberg J, and Griffiss JM.
TI - Does ozone alleviate AIDS diarrhea?
AD - Rehabilitation Medicine Service, San Francisco Veterans
Administration Medical Center (SFVAMC) 94121.
AB - Five patients with acquired immune deficiency syndrome
(AIDS) or AIDS-related complex (ARC) and intractable
diarrhea were treated with daily colonic insufflations of
medical ozone (oxygen/ozone mixture) for 21-28 days. The
daily dose of ozone (O3) ranged from 2.7 to 30 mg. Three
of the four patients whose diarrhea was of unknown
etiology experienced complete resolution, and one patient
had marked improvement. The fifth patient, whose diarrhea
was due to Cryptosporidium, experienced no change. No
consistent change in the absolute number of helper (CD4)
or suppressor (CD8) lymphocytes was detected, and no
obvious changes were seen in the PO2 or the results of
routine hematologic and blood chemistry studies. Patients
had mild to moderate local discomfort during ozone
administration early in the course of treatment, but no
adverse systemic effects were observed. The results of
this series suggest that medical ozone administered by
rectal insufflation is simple, safe, and effective.
Should this simple treatment be used routinely to treat
chronic intractable ARC/AIDS diarrhea?
SO - J Clin Gastroenterol. 1993 Sep;17(2):142-5.