OxyFile #245

Mucormycosis. Adjunctive therapy with hydrogen peroxide.

Author: Blaine DA; Frable MA

Source: Va Med Q 1996 Winter; 123(1):30-2


Mucormycosis is a devastating fungal disease affecting 
mainly diabetic and immunosuppressed patients and frequently 
causing death. Mucor rhizopus, the opportunistic fungus, 
has been controlled via radical extirpation and intravenous 
Amphotericin B. Hyperbaric oxygen also has been used. The 
authors present two interesting patients: 1) A diabetic 
female with rhinoorbital mucormycosis post total maxillectomy 
with recurrent mucormycosis and 2) A diabetic female with 
acute myelogenous leukemia and sphenoid sinus mucormycosis 
post functional endoscopic sinus surgery with residual 
mucormycosis. Both patients were receiving Amphotericin 
B without improvement. Both fungal infections were apparently 
eradicated with 1/2 strength topical hydrogen peroxide 
soaks. It appears the hydrogen peroxide destroys mucor 
and supporting host tissue by oxidation. The authors propose 
adding 1/2 strength topical hydrogen peroxide soaks to 
the list of possible adjunctive treatments of mucormycosis.