Regional Arterial and Tissue Oxygen Tensions in Man During Regional Infusion with Hydrogen Peroxide Solutions Radiology 1967; 88: 589-591 P.A. Germon, D.S. Faust, A. Rosenthal, and L.W. Brady Abstract: Gray and his co-workers (3) demonstrated in tissue culture and in animals a general relationship between radiation sensitivity and oxygen saturation at the time of irradiation. Churchill-Davidson et al. (1) later applied this principle at the clinical level by employing the hyperbaric chamber to increase oxygen saturation of the tumor during the radiation event. Mallams and Jay et al. adapted regional intraarterial infusion technics, evolved through experience with chemotherapeutic agents, to deliver oxygen to the tumor area, using hydrogen peroxide solutions (4, 5). Data from early reports of these methods revealed that significant increases in oxygen tensions could be achieved in arterial and venous blood, muscle, and tumor tissue. The purpose of the present Pilot study was to evaluate the oxygen tensions generated in arterial blood and muscle in animals and patients being regionally infused with hydrogen peroxide solutions.