Treatment of Arteriosclerotic Obstructive Cerebrovascular Disease with Hydrogen Peroxide Vascular Surgery, Vol. 1, No. 2, June 1967 H.C. Urschell Jr., J.W. Finney, L.M. Dyll, G.L. Boland, G.J. Race, B.E. Jay, G. Davis, G.A. Balla Abstract: The intra-arterial infusion of hydrogen peroxide has been employed by the investigators for the past six years as a method of regional oxygenation in the management of a variety of diseases. In some patients so treated, a decrease in the severity of their atherosclerosis was observed. This phenomenon was studied and confirmed by both in vitro and in vivo experimentation. Following confirmation of the reduction of atherosclerosis by intra- arterial hydrogen peroxide, it was employed therapeutically for the first time in a patient with inoperable cerebral vascular insufficiency secondary to arteriosclerosis, which was unresponsive to medical treatment.