OxyFile #167

Treatment of Arteriosclerotic Obstructive Cerebrovascular Disease with 
Hydrogen Peroxide

Vascular Surgery, Vol. 1, No. 2, June 1967

H.C. Urschell Jr., J.W. Finney, L.M. Dyll, G.L. Boland, G.J. Race, 
B.E. Jay, G. Davis, G.A. Balla


The intra-arterial infusion of hydrogen peroxide has been employed by 
the investigators for the past six years as a method of regional 
oxygenation in the management of a variety of diseases.  In some 
patients so treated, a decrease in the severity of their 
atherosclerosis was observed.  This phenomenon was studied and 
confirmed by both in vitro and in vivo experimentation.

Following confirmation of the reduction of atherosclerosis by intra-
arterial hydrogen peroxide, it was employed therapeutically for the 
first time in a patient with inoperable cerebral vascular 
insufficiency secondary to arteriosclerosis, which was unresponsive to 
medical treatment.