Comparison of Arterial and Tissue Oxygen Measurements in Humans Receiving Regional Hydrogen Peroxide Infusions and Oxygen Inhalation Radiology 1968; 91: 669-672 Patricia A. Germon M.D., Donald S. Faust M.D., and Luther W. Brady M.D. Abstract: Following the report of Gray that tumor sensitivity to irradiation increased in an environment containing an increased oxygen concentration (1), interest was stimulated in the possible application of this principle in the treatment of cancer patients. Churchill- Davidson first used the hyperbaric chamber to provide increased oxygen tensions within the body. Mallams, using regional intra-arterial infusion technics, reported that equally high concentrations of oxygen could be delivered to the tumor area with infusions of hydrogen peroxide solutions (2, 3). Because of reports of the ease of Mallams' technic and the beneficial effects of this adjunct to radiation treatment (4, 5) a study was undertaken to evaluate oxygen tensions generated in arterial blood and muscles of animals and patients receiving infusions with hydrogen peroxide solutions.