OxyFile #165

Comparison of Arterial and Tissue Oxygen Measurements in Humans 
Receiving Regional Hydrogen Peroxide Infusions and Oxygen Inhalation

Radiology 1968; 91: 669-672

Patricia A. Germon M.D., Donald S. Faust M.D., and Luther W. Brady 


Following the report of Gray that tumor sensitivity to irradiation 
increased in an environment containing an increased oxygen 
concentration (1), interest was stimulated in the possible application 
of this principle in the treatment of cancer patients. Churchill-
Davidson first used the hyperbaric chamber to provide increased oxygen 
tensions within the body. Mallams, using regional intra-arterial 
infusion technics, reported that equally high concentrations of oxygen 
could be delivered to the tumor area with infusions of hydrogen 
peroxide solutions (2, 3).

Because of reports of the ease of Mallams' technic and the beneficial 
effects of this adjunct to radiation treatment (4, 5) a study was 
undertaken to evaluate oxygen tensions generated in arterial blood and 
muscles of animals and patients receiving infusions with hydrogen 
peroxide solutions.