Comparison of effects on tissue oxygenation of hyperbaric oxygen and intravascular hydrogen peroxide Surgery, Vol. 63, No. 2, pp. 285-290 NORMAN B. ACKERMAN, M.D., Ph.D. FLOYD B. BRINKLEY, B.S. Boston, Mass. From the Department of Surgery, Boston University, Medical Center, and Chemical Research and Development Laboratories, Edgewood Arsenal Abstract: There are numerous pathologic conditions that are related to, or caused by a decrease in tissue oxygenation. These conditions include many cardiovascular and pulmonary diseases, as well as certain infectious and toxic states. During the past few years there has been considerable interest in the experimental use of both hyperbaric oxygen (OHP) and intravascular hydrogen peroxide (H2O2) as techniques for improving tissue oxygenation. Although the mechanisms of action are different, both OHP and H2O2, are effective in increasing tissue oxygen tensions. The present study was designed to compare the effectiveness of these 2 techniques.