TI: Intravenous Hydrogen Peroxide Infusion as a Means of Extrapulmonary Oxygenation DT: 1967 AU: R.L. Fuson, J.A. Kylstra, P. Hochstein, H.A. Saltzman SO: Clinical Research, Vol. 15, 1967, P 74 AB: The intravenous infusion of hydrogen peroxide (H2O2) merits study as a technique for oxygenating blood since one volume of 3% H2O2 solution upon decomposition will liberate 10 volumes of nascent oxygen. For this reason 3% H2O2 in normal saline was infused at a controlled rate into the right ventricle of 12 pigs whose blood catalase activity was only slightly less than in man. The rate of infusion was limited by bubble formation leading to pulmonary and systemic embolization. Increased ambient pressures up to four atmospheres absolute (ATA) in four animals failed to protect from these complications. In eight pigs studied at one ATA, oxygen consumption (VO2) averaged 10 to 12 cc/kg/min, or approximately three times the rate previously reported. Up to 20% of the animal's oxygen consumption could be supplied by intravenous H2O2 without circulatory and respiratory collapse due to formation of bubbles. Three of the eight pigs receiving 20% of their VO2 from infused H2O2 for one hour survived and recovered. All pigs developed severe methemoglobinemia, unresponsive to the infusion of methylene blue. Curiously, blood from the same pigs mixed in vitro with H2O2 did not form methemoglobin. These experiments suggest that the infusion of H2O2 is a hazardous technique suitable for extrapulmonary blood oxygenation to a limited extent only.