TI: Comparison of Arterial and Tissue Oxygen Measurements in Humans Receiving Regional Hydrogen Peroxide Infusions and Oxygen Inhalation DT: October 1968 AU: P.A. Germon, D.S. Faust, L.W. Brady SO: Radiology 91: 669-672, October 1968 AB: Following the report of Gray that tumor sensitivity to irradiation increased in an environment containing an increased oxygen concentration, interest was stimulated in the possible application of this principle in the treatment of cancer patients. Churchill-Davidson first used the hyperbaric chamber to provide increased oxygen tensions within the body. Mallams, using regional intra-arterial infusion technics, reported that equally high concentrations of oxygen could be delivered to the tumor area with infusions of hydrogen peroxide solutions. Because of reports of the ease of Mallams' technic and the beneficial effects of this adjunct to radiation treatment, a study was undertaken to evaluate oxygen tensions generated in arterial blood and muscles of animals and patients receiving infusions with hydrogen peroxide solutions. Although regional intra-arterial infusion systems using hydrogen peroxide have been suggested as a means to increase oxygen concentrations in arterial blood and tissues, data from this study fail to confirm the magnitude of changes previously reported. The magnitude of the measured changes appears related to the rapidity of infusion and the distance of the hydrogen peroxide source from the measuring electrode. It is believed that the high oxygen readings obtained while the electrode and hydrogen peroxide source are in close proximity reflect other factors beside dissolved oxygen. Comparative studies with inhalation of oxygen in high concentrations demonstrated that high arterial oxygen tensions can be produced consistently in patients in the absence of significant cardiopulmonary disease and depressant drugs.