TI: Peripheral Blood Changes in Humans and Experimental Animals Following the Infusion of Hydrogen Peroxide Into The Carotid Artery. DT: June 23, 1982 AU: J.W. Finney, G.A. Balla, G.J. Race, J.T. Mallams SO: Angiology 1965, Vol. 16, pp 62-66 AB: The lethal effect of ionizing irradiation on tissue can be greatly augmented by increasing the oxygen concentration at the time of their exposure. On this premise, studies were initiated in this institution in 1961 to determine the efficacy of hydrogen peroxide as an oxygen source when infused intraarterially immediately before and during irradiation therapy in the management of malignant tumors. The findings have been encouraging, and preliminary reports have been published. Coincidentally, peripheral blood studies were completed on all patients receiving hydrogen peroxide adjuvant therapy. Some increase was noted in one or more formed blood elements; the most consistant changes occurring in those patients being infused into the common or internal carotid artery. The following is a preliminary report on the peripheral blood changes observed in experimental animals and in humans being infused intraarterially with hydrogen peroxide.