OxyFile #98

TI:  Killing of Blood-Stage Murine Malaria Parasites by Hydrogen 

DT:  June 23, 1982

AU:  H.M. Dockrell and J.H.L. Playfair

SO:  Infection and Immunity, Vol. 39, No. 1, 1983, pp 456-459

AB:  Both nonlethal Plasmodium yoelii and lethal Plasmodium 
     berghei were killed in vitro by hydrogen peroxide at 
     concentrations as low as 10(-5) M.  Higher concentrations 
     were required in the presence of added normal erythrocytes.  
     Injection of hydrogen peroxide in vivo significantly reduced 
     P. yoelii parasitemia but had less effect on P. berghei.