OxyFile #83

TI:  Effect of Endovenous Ozone Therapy on Lipid Pattern and 
     Antioxidative Response of Ischemia Cardiopathy Patients

DT:  Not Known

AU:  Frank Hernandez, Silvia Menendez and Rolando Wong

SO:  National Center for Scientific Research, Havana, Cuba.  
     Medical and Surgical Research Center.

AB:  Patients with cardiac infarction have shown a decrease upon 
     gluthathione peroxidase and superoxide dismutase activities, 
     which are beginners in the scavenger processes of lipid 
     peroxide and superoxide radical respectively.  In the 
     present study, the effects of a specific scheme of 
     endovenous ozone therapy on serum lipid pattern and on 
     antioxidant defense system, gluthathione redox system 
     specifically, was investigated in the blood of patients with 
     myocardial infarct.  Twenty-two patients who had an 
     infarction, between one year and three months before the 
     study were treated with ozone by major autohemotherapy 
     during fifteen sessions.  A statistical significance 
     decrease in total cholesterol and low density lipoprotein 
     were observed.  No statistical significance increase on 
     gluthione peroxidase and glucose 6-phosphate dehidrogenase 
     activities were found.  In the case of glucose 6-phosphate 
     dehidrogenase activity, it was increased significantly at 
     5th session of treatment.  No change in lipid peroxidation 
     level was observed.  It was concluded that endovenous ozone 
     therapy in patients with myocardial infarction has a 
     beneficial effect on serum lipid metabolism and provoking 
     the activation of antioxidant protection system.