TI: Immunological Effect of Ozone (O3/O2) in Rheumatic Diseases DT: Not Known AU: Z. Fahmy SO: Augusta-Klinik, 6550 Bad Kreuznach, Germany AB: The therapeutical application of ozone has proven its value in compensated autoimmune diseases as a support of immunsuppressiva therapy. Through ozone therapy, a rapid and effective elimination of pathological macro-molecules and mediators is attained. Ozone and its popularity undoubtedly stems from the fact that it is less toxic than most other immunosuppressiva agents, rather than from is less efficacy. In the absense of any convincing evidence to the contrary, out clinical impression is that ozone is moderately effective in treating severe rheumatoid arthritis and is decreasing steroid requirements. The positive effect of ozone therapy in rheumatoid arthritis does not remain clear as long as the pathogenesis of the disease remains unknown.