OxyFile #75

Evaluation of patients with retinitis pigmentosa receiving 
electric stimulation, ozonated blood, and ocular surgery in Cuba 
[see comments] 

Author:  Berson EL; Remulla JF; Rosner B; Sandberg MA; 
         Weigel-DiFranco C 

Address: Berman-Gund Laboratory, Harvard Medical School, 
         Massachusetts Eye and Ear
         Infirmary, Boston, USA. 

Source:  Arch Ophthalmol, 1996 May, 114:5, 560-3 

Abstract:

OBJECTIVE: To evaluate the effect of intervention with electric 
stimulation, autotransfused ozonated blood, and ocular surgery, 
performed in Cuba, on the course of the common forms of retinitis 
pigmentosa. 

DESIGN: Ocular evaluations over 6 to 8 months before and after 
intervention in Cuba. 

SETTING: Evaluations performed at a US clinical research facility. 

PATIENTS: Ten adult patients aged 25 to 67 years with retinitis
pigmentosa. 

MAIN OUTCOME MEASURES: Visual acuity, visual field area, and 
electroretinogram (ERG) amplitude. RESULTS: No significant change 
in visual acuity or visual field area was observed on average 
between preintervention and postintervention values over a 6- to 
8-month interval. Mean 30-Hz cone ERG amplitude declined by 15.5% 
between preintervention and postintervention values (P = .006). 
When data on change in visual field area from 1 statistically 
significant outlier were excluded from the analysis, a significant 
decline of 12.9% in mean visual field area was observed (P = 
.025). 

CONCLUSIONS: These data support the conclusion that the 
intervention offered in Cuba provides no benefit to patients with 
retinitis pigmentosa as measured by visual acuity, visual field 
area, and ERG. The magnitudes of the mean declines observed in ERG 
amplitude and visual field area over a 6- to 8-month interval, 
relative to those reported in previous studies, raise the 
possibility that this intervention may worsen the course of the 
disease.