TI: Application of Medical Ozone Therapy in Patients with Sickle Cell Anemia, Preliminary Report DT: Nov 1989 AU: Silvia Menendez, Edgardo Espinosa, James A. Caplan and Wilfredo Diaz SO: National Center for Scientific Research, Ozone Research Center, Havana, Cuba. AB: In patients with sickle cell anemia, the reduction in the availability of oxygen to the cells, produces painful crisis, infarction, abdominal and/or muscle pains, ulcer, etc. On the basis of some medical properties of ozone, concerning the ability to increase the rate and the capacity of absorption of oxygen in erythrocytes, and evaluation about the effectiveness of this treatment for the prevention and/or the timely resolution of the crisis was made. For the controlled clinical trial, 55 adult sickle cell anemia patients were studied, each suffering from painful crisis. Two groups were established: control group, comprised of 25 patients who received conventional treatment, and ozone/oxygen treated group, comprising 30 patients who received the same treatment plus ozone therapy, by intrarectal administration, during 15 sessions. The average time required for resolution of painful sickle cell crisis in ozone/oxygen treated patients was half the number of hours required to solve painful crisis in control patients. Frequency and severity of painful crisis in sickle cell anemia patients who received ongoing ozone/oxygen therapy diminished in the six-month-period-follow-up, in comparison with control group patients.