TI: Subatmospheric O2/O3 - Treatment of Therapy-Resistent Wounds and Ulcerations* DT: 1985 AU: Horst Werkmeister SO: OzoNachrichten 4 (1985) Heft 3/4 *Paper presented at the 7th Ozone World Congress Tokyo 9th - 12th Sept. 1985 AB: The treatment of badly healing and generally also severely infected wounds with an ozone/oxygen mixture has to take places within an enclosed system. The effect, in the form of wound disinfection, enhanced circulatory perfusion and stimulated granulation, which is already visible when gas is applied inside what we call a bag - whereby the wound is exposed to the ozone/oxygen mixture for a certain time (approx. 30 minutes per day), is considerably increased when subatmospheric or negative pressure is applied. It is principally the pronounced hyperemia produced by the subatmospheric pressure, in combination with the ozone/oxygen mixture, that stimulates the enzymatic breakdown of necroses, the budding of connective tissue and bloodvessels into the lesion, as well as the covering of the wound with epithelium. As, in the case of the patients treated, we are generally dealing with persons of advanced age who are immobile with circulatory disturbances, and who for the most part are diabetics, the application of subatmospheric gas constitutes a method of wound treatment which is ideal on account of its easy application and convenience to the patient. A further advantage of the method is the possibility of introducing the gas where the wounds are undermined and fistulae are present, thus producing an in-depth effect.