TI: The Biochemical Processes Underlying Ozone Therapy DT: January 1985 AU: R. Viebahn SO: OzoNachrichten 4(1985) Heft 1/2 SU: 1. The efficacy of medical ozone in improving circulation: The so-called circulatory enhancing effects of ozone, as expressed in the form of its being administered intravascularly and intramuscularly, are the result of a direct influence exerted on the oxygen metabolism by the ozone/oxygen mixture applied: a) The formation of peroxides from non-saturated fatty acids, and an influence on the rheological properties of the blood, b) Activation of the cellular enzymal protection system against peroxides, oxygen and ozone. c) Activation of the erythrocytic metabolism and an increase of 2,3-DPG, and d) As a fourth factor, a direct influence of the ozone on the redox function of the mitochondrial respiratory chain is considered: this can be demonstrated, for example, by a significant reduction in NADH. As a total effect, the above properties of ozone bring about a reactivation of the disturbed oxygen metabolism: this is expressed by an increase in the arterial partial oxygen pressure and an enlargement of the arteriovenous pO2 difference, as well as by an increase in deoxygenating substances producing a greater supply of oxygen to the tissues or by improving the actual processing of oxygen by the system. 2. The disinfectant and sterilizing properties of ozone: Due to the different medical application methods of ozone/oxygen mixtures, their different active mechanisms are here to be discussed, i.e.: a) The disinfectant and sterilizing action of ozone is principally a result of its high oxidation potential at E0-2.07V, which is of particular effect when used in the external application of the gas for wound cleaning. It is here quite certain that the germs are killed via a direct oxidative breakdown of the capsid in the microorganisms. b) The situation is different in the treatment of virus- caused complaints such as herpes or hepatitis, in which the principal method is here autohemotherapy (ozone- enriched blood from the patient is reintroduced intravenously). In this method of application, which is the most convenient to the patient, an actual killing of the viruses, which is the case in wound cleaning, cannot here be considered: instead, two, probably synchronous, processes are discussed: a) The inactivation of the viruses by the ozone or its peroxides, and b) An intolerance to peroxides of the virus-infected cells. Thus, as a result of the sequence of biochemical events involved, not only the reaction to O3 itself but also to its reaction products must here also be discussed.