From the National Center for Scientific Research, Ozone Research
Center, P.O. Box 6880, Havana, Cuba.
Abstract: Some bacteria and toxins are not phagocytized by the
reticuloendothelial cells, but instead must be destroyed in some
other way. Fortunately, the body has still another line of
defense called immunity. The blood and other body fluids contain
special proteins called antibodies, that react chemically with
the invading organisms or toxins to destroy them. Antibodies are
gamma globulins, called immunoglobulins and represent 20% of all
the plasmatic proteins. It has recently been demonstrated the
stimulating effects of ozone in the immune system and also its
immunomodulatory properties, according to doses. The aim of this
research was to evaluate the effects, that ozone therapy exerts,
in different immunoglobulins (IgA, IgG and IgM) of children with
humoral immunity deficiency. 61 out-patients, between 1 and 5
years, with humoral immunity deficiency (98% with IgA
deficiency) were studied. Those children suffered, frequently
head cold, tonsillitis, adenoiditis, otitis, asthma and
pneumonia. Ozone was applied (5 days a week) by rectal
insufflation, at age dependent doses, during 3 weeks. During
treatment, no other medication was used. Different
immunoglobulins (IgA, IgG and IgM) were measured at the
beginning and at the end of treatment. For the statistical
significances, Wilcoxon Sum Rank Test was applied. Increases in
IgA and IgG values, with high statistical significant
differences (p<10(-4)), were achieved. Also IgM values
increased, with statistical significant differences (p<0.05).
IgA, IgG and IgM initial and final mean values are shown in
table 1.
Table 1
IgA, IgG and IgM MEAN VALUES AT THE BEGINNING AND END OF
TREATMENT
—————————————————————-
Immunoglobulins Initial Mean Value Final Mean Value P
—————————————————————-
IgA 0.55 p/m 0.01 1.66 p/m 0.07 <10(-4)
IgG 8.10 p/m 0.29 14.89 p/m 0.61 <10(-4)
IgM 0.96 p/m 0.06 1.81 p/m 0.07 <0.05
—————————————————————-
In all patients, humoral immunity was normalized, taking into
account the different immunoglobulins values according to age.
In all patients, clinical improvements were also achieved. 6
months after finishing the treatment, no relapse was found and
all the children increased, in weight and size, in more than 50%
percentile. Ozone therapy, by rectal insufflation was well
tolerated, and no side effects were achieved.
Copyright © 2021 oxygentherapyexperts. All rights reserved.