TI: Studies on the Biological Effects of Ozone: 4. Cytokine
production and glutathione levels in human erythrocytes.
DT: December 14, 1993
AU: V. Bocci, E. Luzzi, E. Corradeschi, L. Paulesu, R. Rossi,
E. Cardaioli, P. DiSimplicio
SO: J Biol Regul Homeost Agents, 1993: 7: 133-8
AB: We have investigated the effect of various concentrations of
ozone on human blood aiming to correlate the production of
cytokines with depletion of reduced glutathione and hemolysis.
As erythrocytes constitute the bulk of blood cells and represent
the main target of ozone they have been taken as a useful marker
of its oxidative activity. It appears that a transient exposure
(30 sec) of blood of up to 78 ug ozone per ml of blood does not
depress the production of cytokines even though there is a slight
increase of hemolysis and a small decrease of intracellular
reduced glutathione. In contrast either a constant (up to 30
sec) exposure of an ozone flux or a high ozone concentration (108
ug/ml) markedly decreases reduced glutathione levels and
depresses cytokine production.
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